C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/117 (2006.01) A61K 31/135 (2006.01) A61P 37/06 (2006.01) C07C 215/42 (2006.01)
Patent
CA 2596990
The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.
L'invention concerne des analogues de sphingosine-1-phosphate puissants, et des agonistes sélectifs au niveau d'un ou de plusieurs récepteurs S1P, notamment le type de récepteur S1P1. Les composés de l'invention contiennent des composés possédant un groupe fonctionnel de phosphate ainsi que des composés à substitut de phosphate résistant à l'hydrolyse notamment des phosphonates, des phosphonates alpha substitués, et des phosphothionates.
Lynch Kevin R.
Macdonald Timothy L.
Gowling Lafleur Henderson Llp
University Of Virginia Patent Foundation
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