Pharmaceutical agent containing rho kinase inhibitor

Details Pharmaceutical agent containing rho kinase inhibitor Pharmaceutical agent containing rho kinase inhibitor

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/444 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2263425

A Rho kinase inhibitor is provided as a novel pharmaceutical agent, particularly as a therapeutic agent of hypertension, a therapeutic agent of angina pectoris, a suppressive agent of cerebrovascular contraction, a therapeutic agent of asthma, a therapeutic agent of peripheral circulation disorder, a prophylactic agent of immature birth, a therapeutic agent of arteriosclerosis, an anti-cancer drug, an anti-inflammatory agent, an immunosuppressant, a therapeutic agent of autoimmune disease, an anti-AIDS drug, a contraceptive, a prophylactic agent of digestive tract infection, a therapeutic agent of osteoporosis, a therapeutic agent of retinopathy and a brain function improving drug, containing an amide compound of the formula: Ra-CO-NR b R c (I) in which R a is an amino(alkyl)-substituted cyclohexyl, an amino(alkyl)-substituted phenyl, pyperidyl or the like, R b is hydrogen, alkyl or the like and R c is optionally substituted N-containing heterocycle. Also disclosed a novel amide compound of the formula: (see formula III) in which L and R5 are hydrogen, alkyl or the like and Rc' is optionally substituted heterocycle other than pyridine.

L'invention concerne des nouveaux médicaments comprenant des inhibiteurs de la Rho kinase, utilisés comme remèdes contre l'hypertension, contre l'angine, inhibiteur des secousses musculaire cérébrovasculaires, remède contre l'artériosclérose, médicament anticancéreux, anti-inflammatoire, immunosupresseur, remède contre les maladies auto-immunes, médicament contre le SIDA, contraceptif, agent de prévention d'infections digestives, remède contre l'ostéoporose, contre la rétinopathie et agent améliorant la fonction cérébrale. L'invention porte aussi sur des réactifs et des agents diagnostiques comprenant des inhibiteurs de la Rho kinase.

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