C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/40 (2006.01) A61K 31/415 (2006.01) A61K 31/422 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2430151
Phenylacetamido-pyrazoles of Formula (I) and, more particularly, N-(5- cycloalkyl-1H-pyrazol-3-yl) phenylacetamido derivatives, optionally further substituted as reported in the description; or pharmaceutically acceptable salts thereof; are useful in the treatment of cell proliferative disorders, e.g.cancer, associated with an altered cell cycle dependent kinase activity. Formula (I).
L'invention concerne des phénylacétamido-pyrazoles de formule (I) et, plus précisément, des dérivés N-(5-cycloalkyle-1H-pyrazole-3-yl) phénylacétamido, éventuellement encore substitués, comme indiqué dans le descriptif; ou leurs sels pharmaceutiquement acceptables; qui conviennent pour le traitement de troubles de prolifération cellulaire, tels que le cancer, associés à une activité de kinase dépendant du cycle cellulaire modifié.
Amici Raffaella
Brasca Maria Gabriella
Longo Antonio
Orsini Paolo
Pevarello Paolo
Pharmacia & Italia S.p.a.
Smart & Biggar
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