Treating androgen decline in aging male (adam)-associated...

A - Human Necessities – 61 – K

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Details

A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) C07K 14/72 (2006.01)

Patent

CA 2501874

The present invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of an Androgen Decline in Aging Male (ADAM)~- associated condition in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof. The present invention further provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, benign prostate hyperplasia or prostate cancer due to ADAM in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof.

L'invention concerne un procédé permettant de traiter, de prévenir, de supprimer, d'inhiber ou de réduire l'incidence d'un état associé au déficit androgénique lié à l'âge chez l'homme (ADAM), par administration d'un composé modulateur sélectif du récepteur des androgènes (SARM) et/ou d'un de ses analogue, dérivé, isomère, métabolite, sel acceptable du point de vue pharmaceutique, produit pharmaceutique, hydrate, N-oxyde, promédicament, polymorphe, cristal, ou toute combinaison de ceux-ci. L'invention concerne en outre un procédé permettant de traiter, de prévenir, de supprimer, d'inhiber ou de réduire l'incidence des états suivants: troubles sexuels, baisse du désir sexuel, troubles de l'érection, hypogonadisme, sarcopénie, ostéopénie, ostéoporose, altérations de la connaissance et de l'humeur, dépression, anémie, chute des cheveux, obésité, hyperplasie bénigne de la prostate ou cancer de la prostate dus au déficit androgénique lié à l'âge chez l'homme, par administration à un patient d'un composé modulateur sélectif du récepteur des androgènes (SARM) et/ou d'un de ses analogue, dérivé, isomère, métabolite, sel acceptable du point de vue pharmaceutique, produit pharmaceutique, hydrate, N-oxyde, promédicament, polymorphe, cristal, ou toute combinaison de ceux-ci.

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