C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 31/7088 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C12N 7/00 (2006.01) C12N 15/48 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2448444
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.
La présente invention concerne des produits de recombinaison d'acides nucléiques contenant des gènes HIV-1 gag/pol, et SIV gag ou SIV env qui ont été mutés de façon que les séquences inhibitrices/instables ont été supprimées et/ou réduites. L'invention se rapporte également à des particules virales et à des cellules hôtes contenant ces produits de recombinaison et/ou ces particules virales. Les produits de recombinaison et les particules virales de l'invention sont utilisés dans la thérapie génique de nombreuses affections, y compris l'infection par le VIH, ou comme vaccin dans l'immunothérapie et l'immunoprophylaxie à HIV-1.
Fetherstonhaugh & Co.
The Government Of The United States Of America
LandOfFree
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