Phenyl-thiophene type vitamin d receptor modulators

Details Phenyl-thiophene type vitamin d receptor modulators Phenyl-thiophene type vitamin d receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61K 31/401 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61P 19/10 (2006.01) C07D 333/16 (2006.01) C07D 333/18 (2006.01) C07D 333/20 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01) C07D 333/34 (2006.01) C07D 333/40 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2485503

The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1.alpha.,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

L'invention concerne des composés non sécosteroïdaux, de phénylthiophène possédant une activité de modulation du récepteur de la vitamine D et qui sont moins hypercalcémiants que la 1?,25 dihydroxyvitamine D3. Ces composés sont utiles dans le traitement maladies des os et du psoriasis.

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