A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C07K 14/775 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2227007
A transgenic nonhuman animal that expresses the human Apo E isoform Apo E2, Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E. Additionally, animals that express more than one of these isoforms are produced by selectively breeding the transgenic animals expressing the different Apo E isoforms disclosed herein. Thus, the present invention allows, among other things, the study of the effects of different combinations of human Apo E isoform expression on normal brain biology, development, function, ageing and injury.
Animal transgénique non humain qui exprime les isoformes Apo E2, Apo E3 ou Apo E4, mais est pratiquement incapable d'exprimer Apo E endogène. De plus, des animaux qui expriment plus d'une de ces isoformes sont produits par reproduction sélective des animaux transgéniques qui expriment les différentes isoformes d'Apo E décrites ici. Par conséquent, la présente invention permet, entre autres, l'étude des effets de différentes combinaisons de l'expression de l'isoforme Apo E humaine sur la biologie normale, le développement, les fonctions, le vieillissement et les lésions du cerveau.
Gilbert John R.
Roses Allen D.
Schmechel Donald E.
Xu Pu-Ting
Duke University
Sim & Mcburney
LandOfFree
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