C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/60 (2006.01) A61K 31/137 (2006.01) A61P 25/28 (2006.01) C07C 213/02 (2006.01) C07C 217/74 (2006.01) C07C 231/12 (2006.01) C07C 235/34 (2006.01)
Patent
CA 2404736
This invention provides a convenient and industrially advantageous process producing amine derivatives having the action of inhibiting the secretion and accumulation of amyloid .beta. protein. (see formula I) (see formula II) (see formula III) (see formula IV) (see formula V) In Compound (I), the ether linkage is selectively cleaved without cleaving the amide linkage present in the same molecule and tertiary amines are not converted into quaternary salts, and thus Amine Derivative (V) with good qualities having the action of inhibiting the secretion and accumulation of amyloid .alpha. protein can be obtained in high yield.
L'invention concerne un procédé qui permet de produire à l'échelle industrielle et sans inconvénient des dérivés d'amine pouvant inhiber la sécrétion et l'accumulation de la protéine bêta-amyloïde. Dans les composés de la formule (I), la liaison éther est rompue sélectivement sans coupure de la liaison amide présente dans la même molécule, et les amines tertiaires ne sont pas transformés en sels quaternaires. On peut ainsi obtenir des dérivés d'amine (V) de bonne qualité, à rendement élevé, qui peuvent inhiber la sécrétion et l'accumulation de la protéine bêta-amyloïde.
Kato Kaneyoshi
Tawada Hiroyuki
Yamashita Makoto
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
Takeda Pharmaceutical Company Limited
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