Method for producing optically active alcohol using an...

Details Method for producing optically active alcohol using an... Method for producing optically active alcohol using an...

C - Chemistry, Metallurgy

12

P

C12P 7/02 (2006.01)

Patent

CA 2691799

A method for producing optically active alcohols of formula (Ia) or (Ib), wherein R1, R2 are alkyl, alkenyl, aryl, or alkylaryl groups, which in turn can be mono-substituted or polsubstituted with alkyl, halogen, SH, SR2, OH OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+ X, wherein R2 , R3 and R4 independently of each other are H or a low-alkyl or low-alkoxy radical, and X is a counterion, with the stipulation that R1 is not identical to R2, by reduction of the corresponding ketone, the reduction being performed with a dehydrogenase having the polypeptide sequence SEQ ID NO:2 or NO:4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified relative to SEQ ID NO:2 or NO:4 by deletion, insertion, substitution, or a combination thereof.

L'invention concerne un procédé de production d'alcools optiquement actifs de formule (Ia) ou (Ib), dans laquelle R1, R2 désignent des groupes alkyle, alcényle, aryle, ou alkylaryle qui peuvent être eux-mêmes mono- ou multisubstitués par alkyle, halogène, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 ou NR2R3R4+X, dans lesquelles R2, R3 et R4 désignent indépendamment les uns des autres H ou un radical alkyle inférieur ou alcoxy inférieur et X- désigne un contre-ion, à condition que R1 soit différent de R2, par réduction de la cétone correspondante, la réduction étant réalisée avec une déshydrogénase comportant la séquence de polypeptides SEQ ID NO:2 ou NO:4, ou une séquence de polypeptides dans laquelle jusqu'à 25 % de radicaux d'acides aminés sont modifiés par rapport à SEQ ID NO:2 ou NO:4 par délétion, insertion, substitution ou une combinaison de ces dernières.

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