A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/38 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61P 27/02 (2006.01) A61P 27/04 (2006.01)
Patent
CA 2430995
The invention provides an ophthalmic aqueous composition for topical administration, comprising:(a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient;(b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer.The invention further provides a method for administering ophthalmic pharmaceuticals.
L'invention concerne une composition ophtalmique aqueuse pour administration topique, comportant : (a) un copolymère bloc d'oxyde de propylène et d'oxyde d'éthylène en concentration suffisante pour présenter une viscosité inférieure à environ 25 centipoises, à température ambiante, et une viscosité d'environ 25 à environ 55 centipoises lorsqu'il est appliqué topiquement à un patient ; (b) de la méthylcellulose hydroxypropyle en concentration suffisante pour améliorer la durabilité du gel formé par le copolymère bloc. L'invention concerne également un procédé d'administration de médicaments ophtalmiques.
Smerbeck Richard V.
Xia Erning
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
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