Indole derivatives as mcp-1 receptor antagonists

Details Indole derivatives as mcp-1 receptor antagonists Indole derivatives as mcp-1 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/42 (2006.01) A61K 31/40 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2295535

The invention concerns pharmaceutically useful indoles of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, as well as pharmaceutical compositions containing them. The novel compounds possess inhibitory activity against monocyte chemoattractant protein-1 (MCP- 1). The invention further concerns the use of such indoles in the treatment of a disease or condition mediated by MCP-1.

Cette invention concerne des indoles utiles du point de vue pharmaceutique correspondant à la formule (I). Dans la formule Z, X, T, A, R?1¿, R?2¿, p et q sont tels qu'ils sont définis dans l'invention. Cette invention concerne également les sels pharmaceutiquement acceptables de ces indoles ou bien leurs esters hydrolysables in vivo, ainsi que des compositions pharmaceutiques contenant ces derniers. Ces nouveaux composés présentent une activité inhibitrice contre la protéine 1 chimiotactique de monocyte (MCP-1). Cette invention concerne également l'utilisation de ces indoles dans le traitement d'une maladie ou d'une pathologie induite par MCP-1.

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