Supersaturated transdermal drug delivery systems, and...

Details Supersaturated transdermal drug delivery systems, and... Supersaturated transdermal drug delivery systems, and...

A - Human Necessities

61

K

A61K 9/70 (2006.01)

Patent

CA 2229184

Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug reservoir components to a predetermined temperature. Generally, this temperature is higher than the depressed melting temperature of the polymer-drug admixture which will serve as the drug reservoir. In an alternative embodiment, wherein heat treatment of the reservoir components results in a system having two liquid phases, the predetermined temperature is calculated so as to be higher than the melting temperature of the pure drug. Drug reservoirs and novel transdermal delivery systems prepared using the disclosed techniques are provided as well.

L'invention concerne des procédés de fabrication de systèmes transcutanés de distribution de médicaments comportant des réservoirs de médicaments sursaturés, de façon à obtenir des débits de médicaments plus élevés. Ces procédés comprennent une étape où l'on chauffe les constituants réservoir de médicament à une température prédéterminée, généralement supérieure à la température de fusion abaissée du mélange polymère-médicament qui servira de réservoir de médicament. Dans un autre mode de réalisation, où le traitement thermique des composants du réservoir produit un système présentant deux phases liquides, la température prédéterminée est calculée de façon à être supérieure à la température de fusion du médicament pur. L'invention concerne également les réservoirs de médicaments et les systèmes de distribution transcutanés originaux préparés selon ces techniques.

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