Platinum complex compound and utilization of the same

Details Platinum complex compound and utilization of the same Platinum complex compound and utilization of the same

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) A61K 31/41 (2006.01) A61P 35/00 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2712408

The present invention provides a novel dinuclear platinum(II) complex compound that can bind to DNA by a mode different from that of cisplatin-type drugs, a method of producing this compound and an anticancer agent comprising this compound as an effective component. This compound is a tetrazolato-bridged platinum complex compound represented by the following formula (I), wherein A is optionally substituted tetrazolato, B is an inorganic or organic anion, and m and n are integers determined in accordance with the charge number of the platinum complex ion and the charge number of the anion.

La présente invention concerne un nouveau composé à base de complexe binucléaire de platine (II) capable de se lier à l'ADN d'une manière différente des préparations de cisplatine, un procédé de production de ce composé et un agent anticancéreux contenant ce composé en tant que principe actif. Le composé décrit ci-dessus est un composé à base de complexe de platine tétrazolato-réticulé représenté par la formule générale (I) suivante, dans laquelle A représente un groupe tétrazolato éventuellement substitué, B représente un anion inorganique ou organique, et m et n sont des nombres entiers qui sont déterminés selon respectivement le nombre de charges de l'ion du complexe de platine et le nombre de charges de l'anion.

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