Pyrazolyl indolyl derivatives as ppar activators

Details Pyrazolyl indolyl derivatives as ppar activators Pyrazolyl indolyl derivatives as ppar activators

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4155 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2557789

This invention is concerned with compounds of the formula (I), wherein one of R6, R7 and R8 is (II), and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

Cette invention se rapporte à des composés représentés par la formule (I), dans laquelle l'un des éléments R?6¿, R?7¿ et R?8¿ représente (a) et R?1¿ à R?15¿ et? ¿n sont définis dans les pièces descriptives de la demande, ainsi qu'à tous les énantiomères et sels et/ou esters pharmaceutiquement acceptables de ces composés. Cette invention concerne en outre des compositions pharmaceutiques contenant ces composés, un procédé servant à leur préparation et leur utilisation dans le traitement et/ou la prévention de maladies qui sont modulées par des agonistes de PPAR.delta. et/ou PPAR.alpha..

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