Recombinant human sm-11044-binding receptor protein having...

Details Recombinant human sm-11044-binding receptor protein having... Recombinant human sm-11044-binding receptor protein having...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2342984

Transformed cells wherein a recombinant human SMBP is expressed at such a high level as enabling the assay of the ligand-binding activity by deleting the polythymidine sequence from the base sequence of the 3'-nontranslation region or the cell membrane fraction thereof; the recombinant human SMBP isolated from these transformed cells or the cell membrane fraction thereof; a method for screening a human SMBP agonist/antagonist characterized by using the above transformed cells, the cell membrane fraction thereof or the isolated recombinant human SMBP; and the human SMBP agonist/antagonist, etc. obtained by the above screening method.

L'invention concerne des cellules transformées dans lesquelles un recombinant humain SMBP est exprimé à un niveau élevé permettant la détermination de l'activité de liaison au ligand par séparation de la séquence polythymidine de la séquence de base de la région de non-translation 3' ou de la fraction de membrane cellulaire de celles-ci. L'invention concerne également le recombinant humain SMBP isolé de ces cellules transformées ou de la fraction de membrane cellulaire de celles-ci, un procédé de dépistage d'un agoniste/antagoniste SMBP humain caractérisé en ce qu'on utilise les cellules transformées précitées, la fraction de membrane cellulaire de celles-ci ou le recombinant humain SMBP isolé, ainsi que l'agoniste/antagoniste SMBP humain, etc. obtenu par le procédé de dépistage précité.

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