Improved chimeric toxin receptor proteins and chimeric toxin...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/095 (2006.01) C07K 14/705 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2617877

Chimeric toxin receptor proteins having a toxin receptor associated with an immunoglobulin complex having least a portion of an immunoglobulin heavy chain and at least a portion of an immunoglobulin light chain are described. Such chimeric toxin receptor proteins have improved stability as compared to chimeric toxin receptor proteins lacking the light chain. Anthrax and botulinum chimeric toxin receptor proteins with increased stability are also described.

La présente invention concerne des protéines chimériques de récepteur de toxines comportant un récepteur de toxines associées à un complexe d~immunoglobuline comportant au moins une partie d'une chaîne lourde d~immunoglobuline et au moins une partie d'une chaîne légère d~immunoglobuline. De telles protéines chimériques de récepteur de toxines présentent une stabilité améliorée par rapport aux protéines chimériques de récepteur de toxines ne comportant pas la chaîne légère. La présente invention concerne également des protéines chimériques de récepteurs de toxine de l~anthrax et de la toxine botulique dont la stabilité est améliorée.

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