C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/220, 260/242
C07D 473/00 (2006.01) A61K 31/52 (2006.01)
Patent
CA 2000154
4-17262/+ Substituted 9H-purines Abstract of the Disclosure The invention relates to novel 9H-purine derivatives, especially to thenovel substituted 9-benzyl-9H-purines of the general formula Image (I), in which Ph is a phenyl radical substituted by halogen, R1 is hydrogen or a free amino group or an amino group that is substituted aliphatically, cycloaliphatically, cycloaliphatically-aliphatically and/or by acyl, and R2 is halogen, lower alkoxy, lower alkyl, a free amino group, or an amino group that is substituted aliphatically, cycloaliphatically, cycloali- phatically-aliphatically and/or by acyl, with the proviso that R2 is other than halogen when Ph is 2-fluorophenyl or 2,5- or 2,6-difluoro- phenyl and R1 is a radical of the formula -N(R11)(R12) (Ia) in which either R11 is hydrogen, methyl or ethyl and R12 is hydrogen, methyl, hydroxymethyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclopentyl or cyclopropylmethyl, or R11 is hydrogen and R12 is methoxymethyl, and with the further proviso that R2 is other than chlorine when Ph is 3-chloro- phenyl, 4-chlorophenyl or 3,4-dichlorophenyl and R1 is N,N-dimethylamino, and to the novel compounds of formula I in which Ph is 2-fluorophenyl or 2,6-difluorophenyl, R1 is N-methylamino or N,N-dimethylamino and R2 is chlorine, and to the salts thereof in each case. These compounds and the salts thereof can be used as pharmaceutical active ingredients and can be manufactured in a manner known per se.
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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