Screening methods using microbial strain pools

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2258547

Methods of screening for antimicrobial agents or other compounds active on a particular strain are described. These methods use pools of strain of cells or microbes in order to screen for activity on many cellular targets in a single screen. The strain or strains in the pool for which growth is inhibited or stimulated are determined; such identification can also provide a means of identifying the cellular target on which a compound is active.

Méthodes d'analyse pour la recherche d'agents antimicrobiens ou d'autres composés actifs sur une souche particulière. Dans ces méthodes, on utilise des groupes de souches de cellules ou de microbes afin d'analyser l'activité sur plusieurs cibles cellulaires en un seul examen. La ou les souches du groupe dont la croissance est inhibée ou stimulée sont déterminées; cette identification peut également constituer un moyen d'identification de la cible cellulaire sur laquelle un composé est actif.

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