C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/33 (2006.01) A61P 7/02 (2006.01) C07D 209/00 (2006.01) C07D 209/42 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 307/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2358047
This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula (I): wherein X is O, S or NR1 which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of formula (I), methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.
L'invention concerne un composé (aminoiminométhyl ou aminométhyl)benzohétéroaryle représenté par la formule (I). Ce composé convient pour inhiber l'activité du Facteur Xa en combinant ledit composé avec une composition contenant le Facteur Xa. L'invention concerne également des compositions contenant les composés représentés par la formule (I), des méthodes de préparation de ces composés, leur utilisation, notamment l'inhibition de la formation de thrombine ou le traitement d'un patient souffrant d'une maladie associée à une quantité excessive de thrombine physiologiquement nocive.
Burns Christopher
Dankulich William P.
Gallagher Timothy F.
Mcgarry Daniel G.
Volz Francis A.
Aventis Pharmaceuticals Inc.
Aventis Pharmaceuticals Products Inc.
Bereskin & Parr
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