Fluorescence based t-type channel assay

Details Fluorescence based t-type channel assay Fluorescence based t-type channel assay

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 31/00 (2006.01) A61K 33/00 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2512798

A fluorescence based assay for compounds that modulate T-type calcium ion channels and that can be adapted to high throughput screening formats. Modulators of T-type channels are useful to correct functional abnormalities. These abnormalities are associated with epilepsy, pain, schizophrenia, depression, anxiety, cardiac arrhythmia, hypertension, certain types of cancer, diabetes, infertility, sexual dysfunction and other undesirable conditions.

L'invention concerne un essai fondé sur la fluorescence pour des composés modulant des canaux ioniques de calcium de type T, et adaptés à des formats de criblage à haut rendement. L'invention concerne des modulateurs de canaux de type T utiles pour corriger des anormalités fonctionnelles. Ces anormalités sont associées à l'épilepsie, la douleur, la schizophrénie, la dépression, l'anxiété, l'arythmie cardiaque, l'hypertension, certains types de cancer, des diabètes, une infertilité, une dysfonction sexuelle et d'autres troubles indésirables.

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