Method for producing a specific antiserum against the...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) C07K 16/30 (2006.01) G01N 33/531 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2330639

The present invention pertains to the field of medicine and may be used for producing a specific antiserum as well as for carrying out immunological diagnoses of malignant tumours. This method for producing an antiserum involves sampling an embryo at the foetal stage from animals of a same genetic type so as to obtain a cell suspension. After immunisation, this method involves sampling spleen cells from the animal, separating lymphocytes and immunising the animal of the same genetic line using the lymphocyte suspension. An antiserum is then obtained and cells originating from healthy organs of the same animals are added to said antiserum. The mixture is finally decanted and the liquid located above the sediments is filtered. In order to carry out a diagnosis, the filtrate is added to the subject's blood and the results are obtained by immuno-fluorescence, by blood tests or using other methods of immunological diagnosis. It is thus possible to diagnose a tumour when the reliable values obtained differ from reference values.

Cette invention se rapporte au domaine de la médecine et peut être utilisée afin de produire un antisérum spécifique et afin d'effectuer des diagnostics immunologiques de tumeurs malignes. Ce procédé de production d'antisérum consiste à prélever un embryon au stade foetal, chez des animaux d'un même type génétique, de manière à obtenir une suspension cellulaire. Après immunisation, on prélève des cellules de la rate chez l'animal, on sépare les lymphocytes et on immunise l'animal de cette même lignée génétique à l'aide de la suspension de lymphocytes. On obtient ensuite un antisérum auquel on ajoute des cellules provenant d'organes intacts de ces mêmes animaux. Le mélange est enfin décanté et le liquide situé au-dessus des sédiments est filtré. Afin d'effectuer un diagnostic, le filtrât est ajouté au sang du sujet, et les résultats sont obtenus par immuno-fluorescence, par examen du sang ou à l'aide d'autre procédés de diagnostic immunologique. Il est ainsi possible de diagnostiquer une tumeur lorsque l'on obtient des valeurs fiables qui diffèrent de valeurs de référence.

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