Medicine containing polysaccharide substances for activating...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/721 (2006.01) A61K 31/731 (2006.01) A61P 11/06 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2407504

The invention concerns the use of at least a polysaccharide substance having at least five saccharide units and comprising at least some single-unit motifs thereof, at least a substituent bearing at least a negative charge selected among the group comprising in particular the sulphate, acetate, phosphate, phosphonate groups, for preparing a medicine for activating apoptosis by increasing the number of apoptosis receptors at the cell surface, said receptors being those of the group comprising Fas, TNF, TRAIL, CD40, preferably Fas and TNF, receptors. Pathologies treated belong to the group of autoimmune diseases, cancers and asthma, and the polysaccharide substance used is preferably sulphated dextran and iotacarrgeenan.

L'invention porte sur l'utilisation d'au moins une substance polysaccharidique présentant au moins cinq unités saccharidiques et comportant sur au moins certains de ses motifs unitaires, au moins un substituant porteur d'au moins une charge négative choisi dans le groupe comprenant notamment les groupements sulfate, acétate, phosphate, phosphonate, pour la préparation d'un médicament pour l'activation de l'apoptose par augmentation du nombre de récepteurs d'apoptose à la surface cellulaire, lesdits récepteurs étant ceux du groupe comprenant les récepteurs Fas, TNF, TRAIL, CD40, de préférence Fas et TNF. Les Pathologies traitees appartiennent au groupe des maladies auto-immunes des cancers et de l'asthme, et la substance polysaccharidique est de préférence du dextrane sufaté ou de l'iotacarraghénane.

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