Preventives/remedies for muscle tissue degenerations

Details Preventives/remedies for muscle tissue degenerations Preventives/remedies for muscle tissue degenerations

A - Human Necessities

61

K

A61K 31/47 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2264101

Preventives/remedies for muscle tissue degenerations containing as the active ingredient quinoline compounds represented by general formula (I) or pharmaceutically acceptable salts thereof. The preventives/remedies exert remarkable inhibitory and improving effects on muscle tissue degenerations such as necrosis, fibrosis or calcification. Thus, they are useful in the prevention and treatment of, in particular, cardiomyopathy, muscular dystrophy, pulmonary fibrosis, etc.

La présente invention a pour objet des compositions destinées au traitement préventif ou curatif de la dégénérescence du tissu musculaire, contenant pour principe actif des composés de quinoléine représentés par la formule générale (I) ou des sels acceptables sur le plan pharmacologique de ceux-ci. Lesdites compositions préventives ou curatives ont des effets remarquables, pour inhibiter et atténuer les différentes formes de dégénérescence du tissu musculaire, telle que la nécrose, la fibrose ou la calcification. Elles sont donc utiles dans la prévention et le traitement, en particulier, de la cardiomyopathie, de la dystrophie musculaire, de la fibrose pulmonaire, etc.

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