Chromane substituted benzimidazole derivatives as acid pump...

Details Chromane substituted benzimidazole derivatives as acid pump... Chromane substituted benzimidazole derivatives as acid pump...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4184 (2006.01) A61P 1/04 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2608582

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R1, R2, R3 , R4 , R5 and R6, R7, R8 and R9 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

La présente invention concerne des composés de formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci, où : A, B, X, R1, R2, R3, R4, R5 et R6, R7, R8 et R9 sont tels que décrits ici ou un sel pharmaceutiquement acceptable, et des compositions qui comprennent de tels composés et l~utilisation de tels composés dans le traitement d~une affection médiée par une activité antagoniste de la pompe à acide telle que, mais sans être limité, un trouble gastro-intestinal, un trouble oesophagien, le reflux gastro-AEsophagien (RGO), un ulcère peptique, un ulcère gastrique, un ulcère duodénal, des ulcères induits par des AINS, une gastrite, une infection à Helicobacter pylori, une dyspepsie, une dyspepsie fonctionnelle, le syndrome de Zollinger-Ellison, la maladie du reflux non érosif (RGO non érosif), des douleurs viscérales, des brûlures d~estomac, des nausées, une AEsophagite, une dysphagie, un ptyalisme, des troubles des voies respiratoires ou de l~asthme.

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