A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2147180
An induction of TNF-.alpha. mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF-.alpha. protein was also elevated locally and systemically. Neutralization of TNF-.alpha. in obese fa/ fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. A method of treating an animal suffering from insulin resistance in obesity linked Type II diabetes mellitus is disclosed. The method includes providing a therap- eutic agent that includes an antagonist to TNF-.alpha. function in a pharmaceutically acceptable carrier substance and administering a pharmacologically effective amount of the therapeutic agent to the animal.
Hotamisligil Gokhan S.
Spiegelman Bruce M.
Dana-Farber Cancer Institute Inc.
Ridout & Maybee Llp
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