Process for preparing 3,3-disubstituted oxindoles and...

Details Process for preparing 3,3-disubstituted oxindoles and... Process for preparing 3,3-disubstituted oxindoles and...

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) C07C 233/11 (2006.01) C07C 233/58 (2006.01) C07C 255/35 (2006.01) C07D 213/61 (2006.01) C07D 241/44 (2006.01) C07D 333/64 (2006.01) C07D 333/66 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2603818

Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-lH-indol-5-yl)-l- methyl-lH-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thio.rho.hene and benzo[b]thiophenone compounds.

La présente invention concerne des procédés pour préparer des composés d'oxindole et de thio-oxindole qui sont utilisés comme précurseurs pour des composés pharmaceutiques. Elle concerne notamment des procédés pour préparer des composés de 5-pyrrole-3,3-oxindole et du 5-(7-fluoro-3,3-diméthyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-méthyl-1H-pyrrole-2-carbonitrile. Cette invention concerne aussi des procédés pour préparer des composés d'iminobenzo[b]thiophène et de benzo[b]thiophénone.

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