C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12M 1/34 (2006.01) C12Q 1/02 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) G01N 33/543 (2006.01) G01N 27/447 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2335299
The present invention provides methods for monitoring disease states in a subject, as well as methods for monitoring the levels of effect of therapies upon a subject having one or more disease states. The methods involve: (i) measuring abundances of cellular constituents in a cell from a subject so that a diagnostic profile is obtained, (ii) measuring abundances of cellular constituents in a cell of one or more analogous subjects so that perturbation response profiles are obtained which correlate to a particular disease or therapy, and (iii) determining the interpolated perturbation response profile or profiles which best fit the diagnostic profile according to some objective measure. In other aspects, the invention also provides a computer system capable of performing the methods of the invention, data bases comprising perturbation response profiles for one or more diseases and/or therapies, and kits for determining levels of disease states and/or therapeutic effects according to the methods of the invention.
L'invention concerne des procédés de surveillance d'états pathologiques chez un sujet, ainsi que des procédés permettant de surveiller le degré d'effet de thérapies sur un sujet présentant une ou plusieurs pathologies. Les procédés comportent les étapes consistant à: (1) mesurer l'abondance de constituants cellulaires d'une cellule provenant d'un sujet de manière à obtenir un profil de diagnostic; (2) mesurer l'abondance de constituants cellulaires d'une cellule d'un ou de plusieurs sujets analogues de manière à obtenir des profils de réactions perturbées qui correspondent à une maladie ou à une thérapie particulière; et (3) déterminer le ou les profil(s) de réactions perturbées interpolé(s) qui correspond(ent) le mieux au profil de diagnostic en fonction d'une mesure objective. Dans d'autres aspects, l'invention concerne également un système informatique capable de mettre en oeuvre les procédés de l'invention, des bases de données comportant des profils de réactions perturbées pour une ou plusieurs maladies et/ou thérapies, et des trousses permettant de déterminer des degrés d'états pathologiques et/ou d'effets thérapeutiques selon les procédés de l'invention.
Friend Stephen H.
Stoughton Roland
Osler Hoskin & Harcourt Llp
Rosetta Inpharmatics Inc.
Rosetta Inpharmatics Llc
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