Substituted 1,3-thiazole compounds, their production and use

Details Substituted 1,3-thiazole compounds, their production and use Substituted 1,3-thiazole compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2404384

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4- pyridyl group having a substituent including no aromatic group or (2) a 1,3- thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

L'invention concerne (1) un composé de 1,3-thiazole dont la position 5 a été remplacée par un groupe 4-pyridyle présentant un substituant sans aucun groupe aromatique ou (2) un composé de 1,3-thiazole dont la position 5 est remplacée par un groupe pyridyle ayant, en position adjacente à un atome d'azote du groupe pyridyle, un substituant sans aucun groupe aromatique. L'un ou l'autre desdits composés présente une excellente activité inhibitrice de p38 MAP kinase.

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