Novel neutrophil inhibitors

Details Novel neutrophil inhibitors Novel neutrophil inhibitors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/04 (2006.01) C07K 1/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 14/535 (2006.01) C07K 16/18 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) F02B 75/02 (2006.01)

Patent

CA 2152599

Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

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