A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/62 (2006.01)
Patent
CA 2556967
This invention generally relates to improvement of the body and skin appearance, for example enhancing the appearance of sagging, wrinkled, or cellulite-afflicted areas of the skin and body, through the local delivery of a nitric oxide donor, for example, using delivery vehicles such as lotions, creams, liquids, and/or transdermal patches. In some embodiments, a delivery vehicle containing a nitric oxide donor, for example, L-arginine (an important biological precursor) or its derivatives in a sufficient concentration to improve the appearance of a selected area of the body may be applied. In certain cases, one or more agents may also be included that aid in the transfer of the nitric oxide donor into the tissue, which may overcome the resistance to transfer into the skin. Non-limiting examples of suitable agents include agents able to create hostile biophysical environments, for instance, choline chloride, magnesium chloride, and/or sodium chloride.
L'invention concerne généralement l'amélioration de l'aspect du corps et de la peau, par exemple, l'amélioration de l'aspect des zones affaissées, ridées ou affectées par la cellulite de la peau et du corps, par l'administration locale d'un donneur d'oxyde nitrique, par exemple, au moyen de supports d'administration tels que lotions, crèmes, liquides et/ou pastilles transdermiques. Dans certains modes de réalisation, un support d'administration comprend un donneur d'oxyde nitrique, par exemple, la L-arginine (un précurseur biologique important) ou ses dérivés dans des concentrations suffisantes pour améliorer l'aspect de la zone choisie du corps. Dans certains cas, un ou plusieurs agents peuvent aussi être inclus, qui favorisent le transfert du donneur d'oxyde nitrique dans la peau. Des exemples non limitatifs d'agents appropriés comprennent des agents capables de créer des environnements biophysiques hostiles, par exemple, le chlorure de choline, le chlorure de magnésium et/ou le chlorure de sodium.
Cassan Maclean
Strategic Science & Technologies Llc
LandOfFree
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