Prion and viral clearance process

Details Prion and viral clearance process Prion and viral clearance process

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) B01D 61/14 (2006.01) C07K 1/16 (2006.01) C07K 1/36 (2006.01) C07K 16/06 (2006.01) C07K 16/34 (2006.01) C12N 7/04 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2379901

Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of prion and virus, and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and with excipient such as polysorbate 80. Additional steps include diafiltration to concentrate the anti-D protein and reduce the concentration. of excipient present.

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