Nucleic acid mutation detection in histologic tissue

Details Nucleic acid mutation detection in histologic tissue Nucleic acid mutation detection in histologic tissue

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/82 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2181147

Methods are provided for detection of target neoplastic nucleic acids in a tissues specimen, including a tumor margin or lymph node, and reagents therefor, wherein the nucloic acids are preferably mutant tumor suppressor genes or proto oncogenes, Methods for treatment of cell proliferative diseases utilizing ribozymes or antisense oligonucleotides specific for the target mutant nucleic acids and/or replacement wild type genes are also disclosed.

L'invention concerne des procédés de détection d'acides nucléiques néoplasiques cible dans un échantillon de tissu, y compris un bord de tumeur ou un ganglion lymphatique, ainsi que des réactifs correspondants, lesdits acides nucléiques étant, de préférence, des gènes mutants suppresseurs de tumeurs ou des proto-oncogènes. Elle concerne également des procédés de traitement de maladies cellulaires prolifératives au moyen de ribozymes ou d'oligonucléotides anti-sens spécifiques des acides nucléiques cible mutants et/ou des gènes de remplacement de type sauvage.

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