C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/079 (2010.01) C12N 5/071 (2010.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2722044
Disclosed herein are cells, that are descendents of marrow adherent stem cells (MASCs), capable of rescuing and/or reversing various neural disorders after transplantation into sites of central nervous system (CNS) or peripheral nervous system (PNS) injury. The cells contain alterations in the methylation state of certain genes, compared to their methylation state in MASCs. Methods of making cells capable of rescuing and/or reversing various neural disorders after transplantation into sites of CNS or PNS injury, by alteration of the methylation status of certain genes, are also provided.
La présente invention concerne des cellules, descendant de cellules souches médullaires adhérentes (MASC), et capables de soigner et/ou de faire régresser diverses affections nerveuses après leur transplantation au niveau de sites lésionnels du système nerveux central (SNC) ou périphérique (SNP). Ces cellules sont caractérisées par une modification de l'état de méthylation de certains gènes, par comparaison avec l'état de méthylation de ces derniers dans les MASC. L'invention concerne également des procédés de production de cellules capables de soigner et/ou de faire régresser diverses affections nerveuses après leur transplantation au niveau de sites lésionnels du SNC ou du SNP, procédés impliquant la modification du statut de méthylation de certains gènes.
Case Casey
Kirby Eades Gale Baker
Sanbio Inc.
LandOfFree
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