A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/575 (2006.01)
Patent
CA 2167537
A hepatitis C virus proliferation inhibitor comprising bile acid or the physiologically acceptable salt thereof as the active principle is disclosed. For the bile acid to be used in the present invention, free bile acids, such as ursodeoxycholic acid and kenodeoxycholic acid, and conjugated bile acids such astauroursodeoxycholic acid can be exemplified. Also, for the physiologically acceptable salt, alkali metal salts such as the sodium salt of bile acid can be exemplified. These bile acid exemplified can remarkably inhibit the proliferation of hepatitis C virus and is also less toxic, and therefore, these can be useful as a hepatitis C virus proliferation inhibitor .
Inhibiteur de prolifération du virus de l'hépatite C renfermant un acide biliaire ou un sel physiologiquement acceptable de cet acide comme principe actif. On peut citer à titre d'exemples d'acides analogues utilisables dans ce cas les acides biliaires libres tels que les acides ursodésoxycholique et chénodésoxycholique, et les acides biliaires conjugués tels que l'acide tauro-ursodésoxycholique. On citera à titre d'exemples de sel les sels de métaux alcalins tels que les sels de sodium. Ces acides ont une action inhibitrice remarquable de la prolifération du virus de l'hépatite C et présentent une très grande sécurité, les rendant ainsi utiles comme inhibiteurs de prolifération de ce virus.
Gowling Lafleur Henderson Llp
Mitsubishi-Tokyo Pharmaceuticals Inc.
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