Pyridine- and quinoline-derivatives

Details Pyridine- and quinoline-derivatives Pyridine- and quinoline-derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/38 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) C07D 221/00 (2006.01) C07D 221/16 (2006.01) C07D 307/00 (2006.01) C07D 311/00 (2006.01) C07D 333/00 (2006.01) C07D 335/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2474460

The present invention relates to compounds of formula (I), wherein R1, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

L'invention concerne des composés de formule générale (I), dans laquelle R<l>, R<2>, R<3> et R<4 >ont la signification indiquée dans la description et dans les revendications, ainsi que des sels pharmaceutiquement acceptables de ceux-ci. Ces composés sont utiles dans le traitement et/ou la prophylaxie de maladies associées au DPP IV, de type diabète, en particulier le diabète insulino-dépendant, et la diminution de la tolérance au glucose.

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