Process for the preparation of imidazopyridines

Details Process for the preparation of imidazopyridines Process for the preparation of imidazopyridines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2101789

Abstract of the Disclosure The invention relates to a novel process for the preparation of imidazopyridines of formula I: Image in which R is alkyl having 1-6 C atoms, characterised in that 3,4-diamino-2-chloropyridine (II) is reacted with an acid anhydride of the formula RCO-O- COR' (III), in which R is as defined and R' is R or can be another aliphatic or aromatic radical, to give a 4-amino-2-chloro-3-R-CO-aminopyridine (IV), this is converted with 4'-bromomethyl-2-cyanobiphenyl (V), in the presence of an alkali metal alcoholate in an inert solvent, to a 4-amino-2-chloro-3-R-CO-[N-(2'-cyano- biphenyl-4-ylmethyl)amino]pyridine (VI) and this is treated with a strong acid, a 2-R-4-chloro-3-(2'-cyano- biphenyl-4-ylmethyl)-3H-imidazo[4,5-c]pyridine (VII) being formed as an intermediate.

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