A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/275 (2006.01) A61K 31/00 (2006.01) A61K 31/277 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 1/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07K 16/40 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2401323
The present invention relates to a method of treating a condition comprising administering a pharmaceutically effective amount of an inhibitor of the Tec family of protein tyrosine kinases (PTKs). The condition is typically associated with cytokine production. Conditions addressed by the invention include sepsis, septic shock, inflammation, rheumatoid arthritis and Crohn's disease. In one embodiment, the condition is induced by zymosan. The invention also provides the use of an inhibitor of a member or members of the Tec family of PTKs in the manufacture of a medicament for use in the treatment of a condition associated with cytokine production and methods for identifying an inhibitor of a member or members of the Tec family of PTKs which is also suitable for use in the treatment of a condition associated with stimulus- induced cytokine production.
L'invention concerne un procédé pour traiter un état qui consiste à administrer au patient une quantité pharmaceutiquement efficace d'un inhibiteur de la famille Tec des protéines tyrosines kinases (PTK), l'état en question étant normalement associé à la production de cytokines. Les états que concerne l'invention comprennent la septicémie, le choc septique, l'inflammation, l'arthrite rhumatoïde et la maladie de Crohn. Dans un mode de réalisation, cet état est provoqué par le zymosan. L'invention concerne aussi l'utilisation d'un inhibiteur d'un ou de plusieurs éléments de la famille des PTK dans la fabrication d'un médicament destiné à être utilisé dans le traitement d'un état associé à la production de cytokines et des procédés pour identifier un inhibiteur d'un ou de plusieurs éléments de la famille des PTK, qui convient aussi pour le traitement d'un état associé à la production de cytokines induite par de stimulus.
Macrae & Co.
Synovis Limited
LandOfFree
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