Compositions and methods for the treatment of tumors

Details Compositions and methods for the treatment of tumors Compositions and methods for the treatment of tumors

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2341304

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment.

L'invention se rapporte à des compositions et à des méthodes permettant de diagnostiquer et de traiter une croissance et une prolifération cellulaire néoplasique chez des mammifères et notamment chez des humains. Les méthodes de cette invention consistent à identifier des gènes qui sont amplifiés dans le génome de cellules tumorales. Une telle amplification de gènes semble être associée à la surexpression du produit génique, par comparaison avec le comportement de cellules normales du même type de tissu, et elle semble donc contribuer à l'action cancérigène. Par conséquent, il semble que les protéines codées par les gènes amplifiés constituent des cibles utiles au diagnostic et au traitement (notamment à la prévention) de certains cancers, et qu'elles peuvent servir d'agents permettant la prévision de l'évolution d'un traitement anti-tumoral.

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