A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/56 (2006.01) A61K 39/00 (2006.01) A61P 37/02 (2006.01) C12N 5/07 (2010.01)
Patent
CA 2315790
The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to reduce the excessive immune response in an individual. This invention is generally directed to autoimmune diseases which involve an excessive immune response or an aberrant/enhanced Th1 response. More specifically, the present invention is directed to the treatment of Crohn's disease and ulcerative colitis, both known as IBD. While the present invention discloses specific information about the treatment of IBD, the disclosure is in no way limiting. Additionally, rheumatoid arthritis, type 1 diabetes mellitus, lupus erythematosis, sarcoidosis and multiple sclerosis can be treated by the methods and compositions disclosed therein.
Cette invention concerne un procédé de traitement d'une réaction immune excessive dont une réaction Th1 aberrante/accrue. Ledit procédé consiste à administrer une préparation à base d'helminthes en quantité suffisante pour réduire la réaction immune excessive chez un individu. Ledit procédé est dirigé, de manière générale, contre les maladies auto-immunes qui impliquent une réaction immune excessive ou une réaction Th1 aberrante/accrue. Plus particulièrement, l'invention concerne un procédé de traitement de la maladie de Crohn et de la rectocolite hémorragique, toutes deux classées comme maladies intestinales inflammatoires. Bien que cette invention présente des informations spécifiques sur le traitement des maladies intestinales inflammatoires, la présentation n'est en aucun cas limitative. En outre, les procédés et les compositions selon l'invention permettent de traiter la polyarthrite rhumatoïde, le diabète sucré du type 1, le lupus érythémateux, la sarcoïdose et la sclérose en plaques.
Elliott David E.
Weinstock Joel V.
Torys Llp
University Of Iowa Research Foundation
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