Quinoline and quinoxaline compounds which inhibit...

Details Quinoline and quinoxaline compounds which inhibit... Quinoline and quinoxaline compounds which inhibit...

C - Chemistry, Metallurgy

07

D

C07D 241/44 (2006.01) A61K 31/47 (2006.01) A61K 31/498 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 215/38 (2006.01)

Patent

CA 2291750

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

L'invention concerne des composés de quinoline/quinoxaline inhibant l'activité du facteur de croissance dérivé des plaquettes ou de la tyrosine-kynase p56?lck¿, des compositions pharmaceutiques renfermant ces composés, et l'utilisation de ces composés pour le traitement de patients souffrant de certains troubles/états associés à la différentiation et à la prolifération cellulaire, à la production de la matrice extracellulaire ou à la libération des médiateurs chimiques et/ou à l'activation ou à la prolifération des lymphocytes T.

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