C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2509767
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N- terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance with the present invention can be used in the treatment or prevention of diseases related to an undesirable activity of MCP proteins such, such as inflammatory disease, autoimmune diseases, vascular diseases, and cancer.
La présente invention concerne de nouveaux antagonistes de protéines MCP, notamment de la protéine MCP-1. Lesdits antagonistes peuvent être obtenus par génération de mutants MCP dont le site de liaison GAG, situé au niveau du N-terminal de protéines MCP, disparaît suite à des substitutions non persistantes. Les composés préparés conformément à la présente invention peuvent être utilisés dans le traitement ou la prévention de maladies associées à une activité indésirable de protéines MCP telles que, les maladies inflammatoires, les maladies auto-immunes, les maladies vasculaires et le cancer.
Handel Tracy
Kosco-Vilbois Marie
Proudfoot Amanda
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Laboratoires Serono S.a.
The Regents Of The University Of California
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