Treating inflammation and related conditions with irindalone

Details Treating inflammation and related conditions with irindalone Treating inflammation and related conditions with irindalone

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 17/08 (2006.01) A61P 17/10 (2006.01) A61P 17/16 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2730385

A method for treating an inflammatory condition or immune disorder comprises administering to a subject having such a condition or disorder a therapeutically effective amount of at least one compound selected from irindalone, physiologically active enantiomers thereof, and pharmaceutically acceptable salts thereof. The invention further provides a method for elevating levels of anti-inflammatory cytokines such as IL- 10 and IL- 13 while inhibiting expression of pro-inflammatory cytokines. A pharmaceutical composition, useful for example in topical treatment of psoriasis, comprises a therapeutically effective amount of at least one compound selected from irindalone, physiologically active enantiomers thereof, and pharmaceutically acceptable salts thereof, in a vehicle comprising at least one pharmaceutically acceptable excipient, the vehicle being adapted for topical administration to skin of a subject.

L'invention concerne un procédé, pour traiter un état inflammatoire ou un trouble immunitaire, qui comporte l'administration à un sujet souffrant d'un tel état ou d'un tel trouble d'une quantité thérapeutique efficace d'au moins un composé sélectionné parmi de l'irindalone, des énantiomères physiologiquement actifs de celle-ci, et des sels actifs de celle-ci, de qualité pharmaceutique. L'invention concerne en outre un procédé pour élever les niveaux des cytokines anti-inflammatoires, telles  IL-20 et IL-13, tout en empêchant l'expression de cytokines pro-inflammatoires. Une composition pharmaceutique, utile par exemple dans le traitement topique du psoriasis, comporte une quantité thérapeutique  efficace d'au moins un composé sélectionné parmi de l'irindalone, des énantiomères physiologiquement actifs de celle-ci, et des sels actifs de celle-ci, de qualité pharmaceutique, dans un véhicule comportant au moins un excipient de qualité pharmaceutique, le véhicule étant conçu pour une administration topique sur la peau d'un sujet.

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