N-phenyl-2-pyrimidine-amine derivatives and process for the...

Details N-phenyl-2-pyrimidine-amine derivatives and process for the... N-phenyl-2-pyrimidine-amine derivatives and process for the...

C - Chemistry, Metallurgy

07

D

C07D 239/02 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 239/28 (2006.01) C07D 401/02 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2617991

The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

L'invention concerne un nouveau dérivé de N-phényl-2-pyrimidine-amine représenté par la formule (1) et son sel, qui sont particulièrement efficaces dans le traitement du cancer chez les animaux à sang chaud, p. ex. cancer du poumon, cancer gastrique, cancer du côlon, cancer du pancréas, hépatome, cancer de la prostate, cancer du sein, leucémie chronique ou aiguë, malignité hématologique, encéphalophyme, cancer de la vessie, cancer du rectum, cancer du col de l'utérus, lymphome, etc. L'invention concerne aussi un procédé de préparation de ce composé, et une composition pharmaceutique destinée à traiter les maladies mentionnées et qui comprend une quantité efficace du composé comme principe actif, ainsi que des excipients inertes pharmaceutiquement acceptables.

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