C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2152267
The subject invention involves anti-inflammatory compounds having structure (I), wherein: (a) -X is cyclic alkyl, having from 4 to 15 carbon atoms; branched alkyl, having from 6 to 15 carbon atoms; or aryl having from 6 to 15 carbon atoms; (b) n is an integer from 0 to 2; (c) -V- is -OC(O-, - N(Q)C(O)-, -N(Q)C(S)-, -C(O)-, -SO2- or -P(O)(OH)-; (d) -Q is hydrogen; or straight or branched chain alkyl, saturated or unsaturated with 1 or 2 double bonds, having from 1 to 6 carbon atoms; or -Q and -X are covalently linked forming a cyclic moiety which includes the nitrogen to which -Q is bonded and from 5 to 20 carbon atoms; (e) Z as -O- or -NH-; when V is -OC(O)-, -Z- is -NH-; (f) -R1 is a hydrophobic moiety; (g) -R2 is a hydrophobic moiety; (h) -R3 is -(CH2)m-A-NH2 or -(CH2)m-A-B-C(NH2)~NH wherein m is an integer from 1 to about 6, -A- is a covalent bond or p-phenyl or p-cyclohexyl, and -B- is a covalent bond or -NH-; (i) -R4 is a hydrophobic moiety; (j) -R5 is -(CH2)m-A-NH2 or -(CH2)m-A-B-C(NH2) =NH wherein m is an integer from 1 to about 6, -A is a covalent bond or p- phenyl or p-cyclohexyl, and -B- is a covalent bond or -NH-; and (k) -Y is hydrogen or methyl. The subject invention also involves pharmaceutical compositions comprising the above compounds, and methods for treating inflammation or pain using such compounds and compositions.
Dimock Stratton Llp
The Procter & Gamble Company
LandOfFree
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