Escape mutants of newcastle disease virus as marker vaccines

Details Escape mutants of newcastle disease virus as marker vaccines Escape mutants of newcastle disease virus as marker vaccines

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/17 (2006.01) C07K 16/10 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2508139

A vaccine against Newcastle Disease contains one or more mutant immunogens of the NDW strain. The mutant immunogen lacks the antigenic binding site on the F glycoprotein which is recognized by the monoclonal antibody mAb 54. Reagent kits and assay methods help to distinguish vaccinated members of a poultry flock from those that may have been infected with wild-type Newcastle Disease virus.

L'invention concerne un vaccin contre la maladie de Newcastle renermant un ou plusieurs immunogènes mutants de la souche du virus de la maladie de Newcastle appelée NDW. L'immunogène mutant est dépourvu du site de liaison antigénique sur la glycoprotéine F que reconnaît l'anticorps monoclonal mAb 54. L'invention concerne également des kits de réactifs et des procédés d'essai qui aident à faire la distinction entre des volailles vaccinées et des volailles susceptibles d'être infectées par le virus de la maladie de Newcastle de type sauvage.

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