C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/29 (2006.01) A61K 31/18 (2006.01) A61K 31/495 (2006.01) A61K 31/64 (2006.01) C07C 311/39 (2006.01) C07C 311/41 (2006.01) C07C 311/58 (2006.01) C07D 207/14 (2006.01) C07D 295/13 (2006.01) C07D 295/26 (2006.01)
Patent
CA 2422709
The invention relates to cinnamic acid guanidides, to a method for the production thereof, to their use as a medicament or diagnostic reagent, and to a medicament containing these compounds. According to the invention, compounds of formula (I), in which R(1), R(2), R(3), R(4), R(5), R(6), and R(7) have the meanings cited in the claims, are excellent cardiovascular therapeutic agents. These are obtained by reacting a compound of formula (II) with guanidine.
L'invention concerne des guanidides d'acide cinnamique substitués, des procédés permettant de les produire, leur utilisation comme médicament ou agent diagnostique et un médicament les contenant. Selon l'invention, les composés de formule (I) dans laquelle R(1), R(2), R(3),R(4), R(5), R(6) et R(7) ont les significations mentionnées dans les revendications, sont d'excellents agents thérapeutiques du système cardio-vasculaire. Ces composés sont obtenus par réaction d'un composé de formule (II) avec de la guanidine.
Bleich Markus
Heinelt Uwe
Hofmeister Armin
Hropot Max
Lang Hans-Jochen
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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