Oligonucleotide compositions and methods for the modulation...

Details Oligonucleotide compositions and methods for the modulation... Oligonucleotide compositions and methods for the modulation...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/711 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274581

Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.

On décrit des compositions et des procédés de diagnostic, de prévention et de traitement des troubles et des dérèglements immunitaires qui peuvent être traités par la modulation de l'activation des lymphocytes T. Dans les formes de réalisation préférées de l'invention on utilise des oligonucléotides qui peuvent spécifiquement s'hybrider avec des acides nucléiques codant les protéines B7.

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