Detection of biomarkers for neuropsychiatric disorders

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2597932

Systems and methods provide a comprehensive high-throughput approach toward the sequential identification, prioritization, verification, and validation of etiologic factors in neuropsychiatric disorders, some of which can also be utilized as biomarkers for these illnesses. The systems and methods determine patterns of gene expression in various tissues from various samples under various experimental and non-experimental conditions, and uses the differences and similarities between the gene expression profiles observed under these conditions to delineate distinct gene expression profiles of risk and treatment of neuropsychiatric disorders.

La présente invention concerne des systèmes et procédés offrant une puissante approche globale pour l'identification séquentielle, la priorisation, la vérification et la validation de facteurs étiologiques dans le cadre de troubles neuropsychiatriques, certains d'entre eux pouvant également convenir comme biomarqueurs de ces maladies. Ces systèmes et procédés, qui permettent de déterminer des profils d'expression génique dans des tissus à partir d'échantillons dans des conditions expérimentales et non expérimentales, utilisent les différences et similitudes entre les profils d'expressions géniques observés dans ces conditions pour délimiter les profils de risques d'expressions géniques distinctes et le traitement de ces troubles neuropsychiatriques.

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