Oral vaccine compositions

Details Oral vaccine compositions Oral vaccine compositions

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 39/10 (2006.01)

Patent

CA 2341352

Oral vaccine formulations are disclosed having microparticles sized such that at least 50 % of the microparticles are less than 5 m, preferably less than 3 m, the microparticles containing antigen entrapped or encapsulated, such as by a solvent evaporation method, by a biodegradable polymer, such as poly (D,L- lactide-co-glycolide). Additionally, oral vaccine formulations are disclosed having nanoparticles sized such that at least 50 % of the microparticles are less than 600 nm, preferably less than 500 nm, the nanoparticles containing antigen entrapped or encapsulated, such as by a coacervation method, by a biodegradable polymer, such as poly (D,L-lactide-co-glycolide). Protective vaccine formulations containing the B. pertussis antigens PTd or a combination of PTd and FHA are provided.

L'invention concerne des formulations de vaccin oral qui comportent des microparticules dont la dimension pour au moins 50 - d'entre elles est inférieure à 5 µm, de préférence inférieure à 3 µm. Ces microparticules contiennent un antigène piégé ou encapsulé, selon une technique d'évaporation de solvant par exemple, par un polymère biodégradable, tel qu'un poly (D,L-lactide-co-glycolide). En outre, l'invention concerne des formulations de vaccin oral qui comportent des nanoparticules dont la dimension pour au moins 50 - d'entre elles, est inférieure à 600 nm, de préférence inférieure à 500 nm. Ces nanoparticules contiennent un antigène piégé ou encapsulé, selon un procédé de coacervation, par exemple par un polymère biodégradable, tel qu'un poly (D,L-lactide-co-glycolide). L'invention traite également de formulations de vaccins protecteurs contenant les antigènes PTd de B. pertussis ou une combinaison de PTd et FHA.

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