Vascular endothelial cell growth factor antagonists

Details Vascular endothelial cell growth factor antagonists Vascular endothelial cell growth factor antagonists

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145985

The present invention provides vascular endothelial cell growth factor (hVEGF) antagonists, including monoc- lonal antibodies, hVEGF receptors, and hVEGF variants that inhibit the mitogenic, angiogenic, or other biological activity of hVEGF. The antagonists thus are useful for the treatment of diseases and disorders characterized by unde- sirable or excessive endothelial cell proliferation or ne- ovascularization. The monoclonal antibodies and receptors of the invention are also useful in diagnostic and analyti- cal methods for determining the presence of hVEGF in a test sample.

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